The Oncology Journal Club Episode 60: How safe is HRT for breast cancer survivors?
Join Eva Segelov, Craig Underhill and Hans Prenen as they chat through the latest papers.
How safe is HRT for breast cancer survivors?
In today’s episode the team talk us through the nuances of HRT as well as dendritic cells, circulating tumour DNA, postpartum breast cancer and much more.
In our ‘The Paper That Changed My Practice’ segment you’ll hear from Jeremy Shapiro and learn all about the KABOOM! regimen.
And don’t miss the amazing paper of the week which asks Does scalp cooling have the same efficacy in black patients receiving chemotherapy for breast cancer?
This Week’s Main Papers:
- Ho WW, et al. Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy. Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2105323118. doi: 10.1073/pnas.2105323118. PMID: 34725151. Access online here.
- Fontana E, et al. Early-Onset Colorectal Adenocarcinoma in the IDEA Database: Treatment Adherence, Toxicities, and Outcomes With 3 and 6 Months of Adjuvant Fluoropyrimidine and Oxaliplatin. J Clin Oncol. 2021 Nov 9:JCO2102008. doi: 10.1200/JCO.21.02008. Epub ahead of print. PMID: 34752136. Access online here.
- Poggio F, et al. Safety of systemic hormone replacement therapy in breast cancer survivors: a systematic review and meta-analysis. Breast Cancer Res Treat. 2021 Nov 3. doi: 10.1007/s10549-021-06436-9. Epub ahead of print. PMID: 34731351. Access online here.
This Week’s Quick Bites:
- Benhaim L, et al. Circulating tumor DNA is a prognostic marker of tumor recurrence in stage II and III colorectal cancer: multicentric, prospective cohort study (ALGECOLS). Eur J Cancer. 2021 Oct 30;159:24-33. doi: 10.1016/j.ejca.2021.09.004. Epub ahead of print. PMID: 34731746. Access online here.
- Jindal S, et al. Postpartum breast cancer has a distinct molecular profile that predicts poor outcomes. Nat Commun. 2021 Nov 3;12(1):6341. doi: 10.1038/s41467-021-26505-3. PMID: 34732713. Access online here.
- Xu B, et al. International Medullary Thyroid Carcinoma Grading System: A Validated Grading System for Medullary Thyroid Carcinoma. J Clin Oncol. 2021 Nov 3:JCO2101329. doi: 10.1200/JCO.21.01329. Epub ahead of print. PMID: 34731032. Access online here.
- Kraehenbuehl L, et al. Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways. Nat Rev Clin Oncol. 2021 Sep 27. doi: 10.1038/s41571-021-00552-7. Epub ahead of print. PMID: 34580473. Access online here.
- Parikh RB, et al. Uptake and Survival Outcomes Following Immune Checkpoint Inhibitor Therapy Among Trial-Ineligible Patients With Advanced Solid Cancers. JAMA Oncol. 2021 Nov 4. doi: 10.1001/jamaoncol.2021.4971. Epub ahead of print. PMID: 34734979. Access online here.
- Zauderer MG, et al. The use of a next-generation sequencing-derived machine-learning risk-prediction model (OncoCast-MPM) for malignant pleural mesothelioma: a retrospective study. Lancet Digit Health. 2021 Sep;3(9):e565-e576. doi: 10.1016/S2589-7500(21)00104-7. Epub 2021 Jul 28. PMID: 34332931; PMCID: PMC8459747. Access online here.
- Hofland, J, et al. Synoptic Reporting of Echocardiography in Carcinoid Heart Disease (ENETS Carcinoid Heart Disease task force). Journal of Neuroendocrinology. 02 November 2021 https://doi.org/10.1111/jne.13060
Amazing Article of the Week:
Dilawari A, et al. Does Scalp Cooling Have the Same Efficacy in Black Patients Receiving Chemotherapy for Breast Cancer? Oncologist. 2021 Apr;26(4):292-e548. doi: 10.1002/onco.13690. Epub 2021 Feb 17. PMID: 33512741; PMCID: PMC8018328. Access online here.
The Paper That Changed My Practice:
Baar J, Tannock I. Analyzing the same data in two ways: a demonstration model to illustrate the reporting and misreporting of clinical trials. J Clin Oncol. 1989 Jul;7(7):969-78. doi: 10.1200/JCO.1989.7.7.969. PMID: 2738626. Access online here.
This Week’s Team:
Professor Eva Segelov
Eva Segelov
Professor Eva Segelov is a Medical Oncologist and is Director of Oncology at Monash University and Monash Health, Melbourne, Victoria, previously Senior Medical Oncologist at St Vincent’s Hospital, St Vincent’s Private Hospital and St Vincent’s Clinic and Associate Professor of Medicine, University of New South Wales.
Eva has an interest in academic clinical trials in GI and breast cancer and has been a member of the AGITG since 2003. She has clinical trials expertise, links with national and international trials groups, and extensive experience with adult medical education. You can find Eva on Twitter here: @profevasegelov
Professor Hans Prenen
Hans Prenen
Professor Hans Prenen is a medical oncologist and head of the phase 1 – early clinical trials unit at the Antwerp University Hospital in Belgium. He is a member of several scientific organisations, published many scientific oncology papers in prestigious journals and is regularly invited for lectures at national and international meetings. His interests are clinical trials and translational research with a focus on digestive oncology. You can find Hans on Twitter here: @HPrenen
Associate Professor Craig Underhill
Craig Underhill
Associate Professor Craig Underhill completed his Bachelor of Medicine and Surgery in 1987 at Melbourne University. He completed medical oncology training in Melbourne and worked as the Senior Clinical Research Registrar at Guy’s Hospital, London.
In 1998 arrived in Albury-Wodonga and established a medical oncology practice and clinical trials unit which has developed expertise and infrastructure to ensure the initiation of high quality trials. The research Unit lead by Dr Underhill has twice been awarded NSW Premier’s Award for Innovation in Cancer Clinical Trials, the inaugural award in 2009 and then again in 2012.
Dr Underhill is the VCCC Regional Oncology Lead and advocates for the increased access to clinical trials for regional Victorians and leads the VCCC teletrials program. You can find Craig on Twitter here: @CraigUnderhill
Associate Professor Jeremy Shapiro
Associate Professor Jeremy Shapiro is a sub-specialist Medical Oncologist at the Cabrini HEALTH, restricting his practice to cancers of the Gastrointestinal and Genitourinary systems
Jeremy is also Associate Professor in the Department of Medicine, Monash University.
You can find Jeremy on Twitter here: @shepster66
Rachael Babin is Editor-in-Chief of The Oncology Newsletter, Publisher of Oncology News Host of The Oncology Podcast and Producer of The Oncology Journal Club. For regular oncology updates for healthcare professionals, please subscribe to The Oncology Newsletter.
With thanks to Eva Segelov, Craig Underhill, Hans Prenen, Jeremy Shapiro and Graham Knowles.
Connect with us on Twitter @OncologyNewsAus
