Today’s episode of The Oncology Journal Club podcast series is an ASCO 2022 Special… Craig Underhill talks to Jeannie Tie about all things ctDNA. Jeanne talks us through the dynamic trial… an overnight success only 12 years in the making.
Compliment with The OJC Episode 23 also featuring Jeanne and The OJC Episode 30: ctDNA Special
This Week’s Paper:
Tie, J, et al. Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer. NEJM. June 4, 2022. DOI: 10.1056/NEJMoa2200075. Access online here.
This Week’s Team:
Professor Craig Underhill

Craig Underhill
Professor Craig Underhill completed his Bachelor of Medicine and Surgery in 1987 at Melbourne University. He completed medical oncology training in Melbourne and worked as the Senior Clinical Research Registrar at Guy’s Hospital, London.
In 1998 arrived in Albury-Wodonga and established a medical oncology practice and clinical trials unit which has developed expertise and infrastructure to ensure the initiation of high quality trials. The research Unit lead by Dr Underhill has twice been awarded NSW Premier’s Award for Innovation in Cancer Clinical Trials, the inaugural award in 2009 and then again in 2012.
Dr Underhill is the VCCC Regional Oncology Lead and advocates for the increased access to clinical trials for regional Victorians and leads the VCCC teletrials program. You can find Craig on Twitter here: @CraigUnderhill
Associate Professor Jeanne Tie

Jeanne Tie
A/Prof Jeanne Tie is the lower gastrointestinal medical oncology and trials lead at the Peter MacCallum Cancer Centre and senior research fellow in the Personalised Oncology Division at the Walter and Eliza Hall Institute of Medical Research. Her translational research focusses on personalising treatment for patients with colorectal cancer with prognostic and predictive biomarkers, in particular the clinical applications of circulating tumour DNA (ctDNA). She leads several ctDNA-based randomized clinical trials in colorectal cancer which aim to assess the clinical utility of ctDNA in guiding adjuvant treatment decision.
Find Jeanne on Twitter here: @JeanneTie
Rachael Babin

Rachael Babin
Rachael Babin is Editor-in-Chief of The Oncology Newsletter, Publisher of Oncology News, Host of The Oncology Podcast and Producer of The Oncology Journal Club podcast.
With thanks to Craig Underhill, Jeanne Tie and Graham Knowles.
Connect with us on Twitter @OncologyNewsAus