Breast cancer is a major cause of patient deaths and often leads to significant life changes even after survival. This paper aims to investigate therapeutic alternatives using nanoparticles to specifically target and treat lymphatic metastasis, a particularly dangerous aspect of breast cancer. It explores the effectiveness and importance of nanoparticle-based therapies in preventing the harmful consequences of breast cancer progression.
The paper starts by discussing the development of lymphatic metastasis and then examines the use of nanoparticle technology in imaging, diagnostics, and therapy. It provides detailed information on primary targeting treatments, including chemotherapy that targets cancer stem cells, induction of tumour cell death, suppression of Epithelial-Mesenchymal Transition (EMT), manipulation of the Tumour Microenvironment (TME), and enhancement of the immune response.
Additionally, the research explores nanoparticle technology in treatment plans, focusing on its super magnetic capabilities and the application of gold nanoparticles, nanodiamonds, and other related features. Nanoparticle technology presents a promising strategy to address lymphatic metastasis in breast cancer by delivering drugs or therapeutic substances directly to cancerous tumours, targeting cancer cells to destroy them or slow their growth. This method provides a solution for administering pharmaceuticals or substances that may be challenging to deliver using conventional methods.
Moreover, nanoparticles help visualise tumours, assisting healthcare professionals in assessing the severity of malignancy and developing appropriate treatment strategies. The paper discusses various nanoparticles used to inhibit the spread of cancer cells from the primary organ to secondary organs.
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Even after overcoming breast cancer, patients remain at risk of post-surgical metastases in vital organs such as the lungs, brain, and bones. The advancements achieved through nanoparticle technology are highly significant. The discussion includes experimental evidence from researchers who mostly conducted studies on mice to support their findings.
Source: Bentham Science Publishers
