In a ground-breaking study published in JAMA Network Open, researchers have found that exercise interventions significantly reduce depression and anxiety while improving the quality of life for older adults with cancer. The systematic review and meta-analysis, led by Rou Yi Soong and colleagues from the National University of Singapore, examined 27 randomised clinical trials (RCTs) involving 1,929 participants over the age of 60.
The study highlights the growing recognition of exercise as more than just a physical health tool. According to the findings, exercise therapy, particularly mind-body practices like tai chi, yoga, and qigong, offers notable mental health benefits for cancer patients. The meta-analysis showed a moderate reduction in depression (Standardised Mean Difference [SMD] = -0.53) and anxiety (SMD = -0.39), alongside significant improvements in health-related quality of life (HRQOL) (SMD = 0.63).
The researchers emphasised that exercise should be considered an integral part of cancer care, particularly for older adults who often face heightened psychological stress. They noted that mind-body exercises were especially effective, highlighting the importance of holistic approaches in medical treatment.
The study’s comprehensive analysis covered trials from various countries, focusing on patients with different cancer types, including prostate, lung, breast, and colorectal cancers. While conventional exercises like aerobic and resistance training showed benefits, mind-body exercises delivered the most significant improvements in mental health outcomes.
Healthcare professionals and policymakers are encouraged to integrate structured exercise programs into standard oncology care. The findings suggest that interventions lasting 12 weeks or more yield the greatest psychological benefits.
With cancer cases rising globally, addressing the mental health of survivors is becoming increasingly critical. The study underscores that exercise isn’t just about physical fitness; it’s a powerful, underutilised tool for mental resilience.
This research offers hope and a clear directive: physical activity can be a prescription for mental well-being, even amidst the challenges of cancer.
Paper: Soong, R Y, et al. Exercise Interventions for Depression, Anxiety, and Quality of Life in Older Adults With Cancer: A Systematic Review and Meta-Analysis. JAMA Network Open. February 4, 2025. doi:10.1001/jamanetworkopen.2024.57859
