The Oncology Journal Club Episode 10

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Today’s must-listen episode includes an in-depth review of two key papers, Quick Bites and an interview with Professor Fran Boyle on burnout.

Eva has an oldie but a goodie on fertility preservation that has wide implications and Hans gives his expert analysis on identifying hereditary colorectal cancer syndromes.

This week our special interview is with the wonderful Professor Fran Boyle – Medical Oncologist from Sydney with a passionate interest in communication skills and burnout. In this episode Fran and Craig discuss a recently published paper on burnout. There’s a companion episode too packed with lots of practical tips to help you prevent and manage burnout: Managing Burnout: Extended Interview with Fran Boyle.

We also have Quick Bites including an ASCO Guideline update on chemotherapy-induced peripheral neuropathy and other papers on metastatic urothelial carcinoma, docetaxel for early breast cancer and BMI, and multi-cancer detection using methylation signatures.

With the usual top quality banter, papers you won’t hear of anywhere else and expert analysis from our Hosts, you are in for another great episode of The Oncology Journal Club!

About The Oncology Journal Club:

We have taken an old concept and updated it with a new format. In each episode a team of expert contributors will review topical journal papers and interview special guests who are leaders in their fields to help keep you informed of the latest developments on the go.

With The Oncology Podcast – and The Oncology Journal Club in particular – we are aiming to deliver oncology news differently,” Rachael Babin, Editor-in-Chief, Oncology News.

Today’s episode is hosted by Professor Eva Segelov, from Monash University. Eva is joined by Dr Craig Underhill from Albury-Wodonga and Professor Hans Prenen from Antwerp, Belgium. We hope you enjoy listening and find this a valuable and entertaining resource. Please let us know what you think!

This Week’s Papers:

Main Papers:

  1. Lambertini, Matteo et al. Gonadotropin-Releasing Hormone Agonists During Chemotherapy for Preservation of Ovarian Function and Fertility in Premenopausal Patients With Early Breast Cancer: A Systematic Review and Meta-Analysis of Individual Patient–Level Data. Journal of Clinical Oncology 36, no. 19 (July 01, 2018) 1981-1990. DOI: 10.1200/JCO.2018.78.0858. Access online here.
  2. Laghi, L., Ricciardiello, L. The changing approach for identifying hereditary colorectal cancer syndromes. Nat Rev Gastroenterol Hepatol (2020). Access online here.

Guest Interview:

In today’s episode we have a special interview on Burnout with Craig Underhill and Fran Boyle. Amongst other things, they discuss the following papers:

  1. West CP, Dyrbye LN, Sinsky C, et al. Resilience and Burnout Among Physicians and the General US Working Population. JAMA Netw Open. 2020;3(7):e209385. doi:10.1001/jamanetworkopen.2020.9385. Access online here.
  2. Goroll AH. Addressing Burnout—Focus on Systems, Not Resilience. JAMA Netw Open. 2020;3(7):e209514. doi:10.1001/jamanetworkopen.2020.9514. Access online here.

Quick Bites:

  1. Loprinzi CL, et al. Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update [published online ahead of print, 2020 Jul 14]. J Clin Oncol. 2020;JCO2001399. doi:10.1200/JCO.20.01399. Access online here.
  2. Apolo AB, et al. Cabozantinib in patients with platinum-refractory metastatic urothelial carcinoma: an open-label, single-centre, phase 2 trial [published online ahead of print, 2020 Jul 6]. Lancet Oncol. 2020;S1470-2045(20)30202-3. doi:10.1016/S1470-2045(20)30202-3. Access online here.
  3. Desmedt C, Fornili M, Clatot F, et al. Differential Benefit of Adjuvant Docetaxel-Based Chemotherapy in Patients With Early Breast Cancer According to Baseline Body Mass Index [published online ahead of print, 2020 Jul 2]. J Clin Oncol. 2020;JCO1901771. doi:10.1200/JCO.19.01771. Access online here.
  4. Liu, M.C et al .Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA. Annals of Oncology, Volume 31, Issue 6, 745 – 759 Access online here.

Access Program Update:

Pembrolizumab access program in the adjuvant setting – more information here.

This Week’s Team:

Professor Eva Segelov

Eva Segelov

Professor Eva Segelov is a Medical Oncologist and is Director of Oncology at Monash University and Monash Health, Melbourne, Victoria, previously Senior Medical Oncologist at St Vincent’s Hospital, St Vincent’s Private Hospital and St Vincent’s Clinic and Associate Professor of Medicine, University of New South Wales.

Eva has an interest in academic clinical trials in GI and breast cancer and has been a member of the AGITG since 2003. She has clinical trials expertise, links with national and international trials groups, and extensive experience with adult medical education.

Professor Hans Prenen

Hans Prenen

Professor Hans Prenen is a medical oncologist and head of the phase 1 – early clinical trials unit at the Antwerp University Hospital in Belgium. He is a member of several scientific organisations, published many scientific oncology papers in prestigious journals and is regularly invited for lectures at national and international meetings.  His interests are clinical trials and translational research with a focus on digestive oncology.



Dr Craig Underhill

Craig Underhill

Dr Craig Underhill completed his Bachelor of Medicine and Surgery in 1987 at Melbourne University. He completed medical oncology training in Melbourne and worked as the Senior Clinical Research Registrar at Guy’s Hospital, London.

In 1998 arrived in Albury-Wodonga and established a medical oncology practice and clinical trials unit which has developed expertise and infrastructure to ensure the initiation of high quality trials. The research Unit lead by Dr Underhill has twice been awarded NSW Premier’s Award for Innovation in Cancer Clinical Trials, the inaugural award in 2009 and then again in 2012.

Dr Underhill chaired a working party that was instrumental in securing $65 million in federal funding for The Albury Wodonga Regional Cancer Centre which opened in September 2016.

Dr Underhill is the VCCC Regional Oncology Lead and advocates for the increased access to clinical trials for regional Victorians and leads the VCCC teletrials program.

Fran Boyle

Fran Boyle is a Medical Oncologist at North Sydney’s Mater Hospital, where she is Director of the Patricia Ritchie Centre for Cancer Care and Research, and Professor of Medical Oncology. She has been involved in research and teaching in communication in health care for the past 20 years, and is currently Director of the Pam McLean Centre in the Sydney Medical School.

Understanding professional burnout, and its relationship to empathy, teamwork and communication, has been a focus for the Pam McLean team. The more so as they find themselves trying to be balanced during crazy times with COVID.

Rachael Babin

Rachael Babin

Rachael Babin is Editor-in-Chief of The Oncology Newsletter and Publisher of For regular oncology updates for healthcare professionals, please subscribe to The Oncology Newsletter.

With thanks to Eva Segelov, Craig Underhill, Hans Prenen, Fran Boyle and Graham Knowles.


About Author

ONA Editor

The ONA Editor curates oncology news, views and reviews from Australia and around the world for our readers. In aggregated content, original sources will be acknowledged in the article footer.

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