The OJC 55: The Gut Microbiota, Electronic Health Records and COVID Risks

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The Oncology Journal Club Episode 55: The Gut Microbiota, Electronic Health Records and COVID Risks

This week Eva talks us through a paper which will be very helpful for current practice. It looks at risk prediction of COVID-19 related deaths and hospital admissions in adults after vaccination.

Hans buried himself in Science and Cell papers this week for his main paper and quick bites. All are focused on the microbiota, the role of bacteria and following an elemental diet. Fascinating stuff!

And Craig brings us back down to the ground with a practice changing paper. He looks at oncology patients’ perception of physicians who use an integrated electronic health record (EHR) during clinic visits.

You’ll also find out key trends in drug revenue among major pharmaceutical companies, how a Geriatric Assessment–Driven Intervention reduced chemotherapy-related toxic effects in older adults with cancer and why the day of the week you submit effects publication rates in peer reviewed journals.

In ‘The Paper That Changed My Practice’ segment we hear from our friend Nathan Cherny with a beautifully poignant paper.

This Week’s Papers:

  1. Haider A, et al. Oncology patients’ perception of physicians who use an integrated electronic health record (EHR) during clinic visits: PRIME-EHR double-blind, randomized controlled trial. Cancer. 2021 Nov 1;127(21):3967-3974. doi: 10.1002/cncr.33778. Epub 2021 Jul 15. PMID: 34264520. Access online here.
  2. Lam KC, et al. Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment. Cell. 2021 Oct 14;184(21):5338-5356.e21. doi: 10.1016/j.cell.2021.09.019. Epub 2021 Oct 7. PMID: 34624222. Access online here.
  3. Hippisley-Cox J, et al. Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study. BMJ. 2021 Sep 17;374:n2244. doi: 10.1136/bmj.n2244. Erratum in: BMJ. 2021 Sep 20;374:n2300. PMID: 34535466; PMCID: PMC8446717. Access online here.

This Week’s Quick Bites:

  1. Pernigoni N, et al. Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis. Science. 2021 Oct 8;374(6564):216-224. doi: 10.1126/science.abf8403. Epub 2021 Oct 7. PMID: 34618582. Access online here.
  2. Tanaka Y, et al. Effects of an elemental diet to reduce adverse events in patients with esophageal cancer receiving docetaxel/cisplatin/5-fluorouracil: a phase III randomized controlled trial-EPOC 2 (JFMC49-1601-C5). ESMO Open. 2021 Oct 6;6(5):100277. doi: 10.1016/j.esmoop.2021.100277. Epub ahead of print. PMID: 34626918. Access online here.
  3. Shah M, et al. The Drug-Dosing Conundrum in Oncology – When Less Is More. N Engl J Med. 2021 Oct 14;385(16):1445-1447. doi: 10.1056/NEJMp2109826. Epub 2021 Oct 9. PMID: 34623789. Access online here.
  4. Meyers DE, et al. Trends in drug revenue among major pharmaceutical companies: A 2010-2019 cohort study. Cancer. 2021 Oct 6. doi: 10.1002/cncr.33934. Epub ahead of print. PMID: 34614198. Access online here.
  5. Li D, et al. Geriatric Assessment–Driven Intervention (GAIN) on Chemotherapy-Related Toxic Effects in Older Adults With Cancer: A Randomized Clinical Trial. JAMA Oncol. Published online September 30, 2021. doi:10.1001/jamaoncol.2021.4158 Access online here.
  6. Phelip JM, et al. Modified FOLFIRINOX versus CisGem first-line chemotherapy for locally advanced non resectable or metastatic biliary tract cancer (AMEBICA)-PRODIGE 38: Study protocol for a randomized controlled multicenter phase II/III study. Dig Liver Dis. 2019 Feb;51(2):318-320. doi: 10.1016/j.dld.2018.11.018. Epub 2018 Nov 28. PMID: 30581069. Access online here.
  7. Berghoff, A.S. et al. Female leadership in oncology—has progress stalled? Data from the ESMO W4O authorship and monitoring studies. ESMO Open, Published:October 18, 2021. Access online here.

Amazing Paper of the Week:

Ausloos, M. et al. Day of the week effect in paper submission/acceptance/rejection to/in/by peer review journals. Physica A: Statistical Mechanics and its Applications. Volume 456, 2016, Pages 197-203, ISSN 0378-4371. Access online here. 

The Paper That Changed My Practice:

Angell M. The quality of mercy. N Engl J Med. 1982 Jan 14;306(2):98-9. doi: 10.1056/NEJM198201143060210. PMID: 7053494. Access online here.

Other Episodes Mentioned:

This Week’s Team:

Professor Eva Segelov

Eva Segelov

Professor Eva Segelov is a Medical Oncologist and is Director of Oncology at Monash University and Monash Health, Melbourne, Victoria, previously Senior Medical Oncologist at St Vincent’s Hospital, St Vincent’s Private Hospital and St Vincent’s Clinic and Associate Professor of Medicine, University of New South Wales.

Eva has an interest in academic clinical trials in GI and breast cancer and has been a member of the AGITG since 2003. She has clinical trials expertise, links with national and international trials groups, and extensive experience with adult medical education. You can find Eva on Twitter here: @profevasegelov

Professor Hans Prenen

Hans Prenen

Professor Hans Prenen is a medical oncologist and head of the phase 1 – early clinical trials unit at the Antwerp University Hospital in Belgium. He is a member of several scientific organisations, published many scientific oncology papers in prestigious journals and is regularly invited for lectures at national and international meetings.  His interests are clinical trials and translational research with a focus on digestive oncology. You can find Hans on Twitter here: @HPrenen


Associate Professor Craig Underhill

Craig Underhill

Associate Professor Craig Underhill completed his Bachelor of Medicine and Surgery in 1987 at Melbourne University. He completed medical oncology training in Melbourne and worked as the Senior Clinical Research Registrar at Guy’s Hospital, London.

In 1998 arrived in Albury-Wodonga and established a medical oncology practice and clinical trials unit which has developed expertise and infrastructure to ensure the initiation of high quality trials. The research Unit lead by Dr Underhill has twice been awarded NSW Premier’s Award for Innovation in Cancer Clinical Trials, the inaugural award in 2009 and then again in 2012.

Dr Underhill is the VCCC Regional Oncology Lead and advocates for the increased access to clinical trials for regional Victorians and leads the VCCC teletrials program. You can find Craig on Twitter here: @CraigUnderhill 

Nathan Cherny:

Nathan Cherny is married (to Nancy) with four children (Gil, Eitan, Noa and Calanit). He lives in Maccabim, central Israel. He was born in Melbourne, Australia, and studied medicine at Monash University Medical School.

In 1994 Dr Cherny joined with Prof Raphael Catane to establish the Oncology and Palliative Medicine Unit at the Shaare Zedek Hospital in Jerusalem. The model and standards for integrated oncology and palliative care developed by Prof Cherny and Prof Catane have since served as the basis for the designation criteria for the ESMO Designated Center program in Integrated Oncology and Palliative Care.  He continues to head the Multidisciplinary Cancer Pain and Palliative Medicine Service at Shaare Zedek Medical Center, and, in addition, he maintains an active practice in general oncology. He runs a mentorship program for Palestinian oncologists from the West Bank and for the Al-sadeel Palliative Care Society in Bethlehem.

In 1999 he helped established the European Society of Medical Oncology Palliative Care Working Group. He is the current chair of the ESMO  magnitude of clinical benefit scale working group. In 2019 he was awarded Member of the Order of Australia. Connect with Nathan on Twitter here: @ChernyNathan

Rachael Babin

Rachael Babin is Editor-in-Chief of The Oncology Newsletter, Publisher of Oncology News Host of The Oncology Podcast and Producer of The Oncology Journal Club. For regular oncology updates for healthcare professionals, please subscribe to The Oncology Newsletter.

With thanks to Eva Segelov, Craig Underhill, Hans Prenen, Nathan Cherny and Graham Knowles.

Connect with us on Twitter @OncologyNewsAus


About Author

The ONA Editor curates oncology news, views and reviews from Australia and around the world for our readers. In aggregated content, original sources will be acknowledged in the article footer.

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