The OJC 53: An Urgent Call to Raise the Bar in Oncology

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The Oncology Journal Club Episode 53: An Urgent Call to Raise the Bar in Oncology

Welcome to this week’s episode of The OJC.

Join Eva Segelov, Craig Underhill and Hans Prenen as they chat through the latest papers. This week Hans gets stuck in Nature offering insights into the origins of pancreatic cancer. Craig has an urgent call to raise the bar in oncology. And Eva looks at treatment options for liver-only metastatic colorectal cancer.

Quick bites are diverse as ever covering smoking cessation, out of pocket medical expenses and you’ll also hear a case report on restless anal syndrome. Yep, only on the OJC!

Drop us a line on Twitter with any comments @oncologynewsaus

This Week’s Papers:

  1. Wood LD, et al. Insights into the origins of pancreatic cancer. Nature. 2021 Sep;597(7878):641-642. doi: 10.1038/d41586-021-02435-4. PMID: 34526690. Access online here.
  2. Zimmers TA. Tumours block protective muscle and nerve signals to cause cachexia. Nature. 2021 Sep 21. doi: 10.1038/d41586-021-02492-9. Epub ahead of print. PMID: 34548663. Access online here.
  3. Schnog JB, et al. An urgent call to raise the bar in oncology. Br J Cancer. 2021 Aug 16:1–9. doi: 10.1038/s41416-021-01495-7. Epub ahead of print. PMID: 34400802; PMCID: PMC8365561. Access online here.
  4. Kanemitsu Y, et lal. Hepatectomy Followed by mFOLFOX6 Versus Hepatectomy Alone for Liver-Only Metastatic Colorectal Cancer (JCOG0603): A Phase II or III Randomized Controlled Trial. J Clin Oncol. 2021 Sep 14:JCO2101032. doi: 10.1200/JCO.21.01032. Epub ahead of print. PMID: 34520230. Access online here.  
  5. Booth CM, et al. Perioperative Chemotherapy for Resectable Liver Metastases in Colorectal Cancer: Do We Have a Blind Spot? J Clin Oncol. 2021 Sep 24:JCO2101972. doi: 10.1200/JCO.21.01972. Epub ahead of print. PMID: 34559553. Access online here.

This Week’s Quick Bites:

  1. Lentz RW, et al. Transarterial Radioembolization in Patients With Unresectable Colorectal Cancer Liver Metastases. J Clin Oncol. 2021 Sep 20:JCO2101993. doi: 10.1200/JCO.21.01993. Epub ahead of print. PMID: 34541862. Access online here.
  2. Nathan P, et al. Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma. N Engl J Med. 2021 Sep 23;385(13):1196-1206. doi: 10.1056/NEJMoa2103485. PMID: 34551229. Access online here.
  3. Casali, P.G. et al. Gastrointestinal stromal tumours: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up†. Annals of Oncology, September 21, 2021, DOI: Access online here.
  4. Sheikh M, et al. Postdiagnosis Smoking Cessation and Reduced Risk for Lung Cancer Progression and Mortality : A Prospective Cohort Study. Ann Intern Med. 2021 Sep;174(9):1232-1239. doi: 10.7326/M21-0252. Epub 2021 Jul 27. PMID: 34310171. Access online here.
  5. Rodríguez de Dios N, et al. Randomized Phase III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small-Cell Lung Cancer (PREMER): A GICOR-GOECP-SEOR Study. J Clin Oncol. 2021 Oct 1;39(28):3118-3127. doi: 10.1200/JCO.21.00639. Epub 2021 Aug 11. PMID: 34379442. Access online here.
  6. Rodriguez-Acevedo AJ, et al. Out-of-pocket medical expenses compared across five years for patients with one of five common cancers in Australia. BMC Cancer. 2021 Sep 25;21(1):1055. doi: 10.1186/s12885-021-08756-x. PMID: 34563142; PMCID: PMC8466922. Access online here.

Amazing Paper of the Week:

  1. Nakamura, I., et al. Case report of restless anal syndrome as restless legs syndrome variant after COVID-19. BMC Infect Dis 21, 993 (2021). Access online here.

This Week’s Team:

Professor Eva Segelov

Eva Segelov

Professor Eva Segelov is a Medical Oncologist and is Director of Oncology at Monash University and Monash Health, Melbourne, Victoria, previously Senior Medical Oncologist at St Vincent’s Hospital, St Vincent’s Private Hospital and St Vincent’s Clinic and Associate Professor of Medicine, University of New South Wales.

Eva has an interest in academic clinical trials in GI and breast cancer and has been a member of the AGITG since 2003. She has clinical trials expertise, links with national and international trials groups, and extensive experience with adult medical education. You can find Eva on Twitter here: @profevasegelov

Professor Hans Prenen

Hans Prenen

Professor Hans Prenen is a medical oncologist and head of the phase 1 – early clinical trials unit at the Antwerp University Hospital in Belgium. He is a member of several scientific organisations, published many scientific oncology papers in prestigious journals and is regularly invited for lectures at national and international meetings.  His interests are clinical trials and translational research with a focus on digestive oncology. You can find Hans on Twitter here: @HPrenen


Associate Professor Craig Underhill

Craig Underhill

Associate Professor Craig Underhill completed his Bachelor of Medicine and Surgery in 1987 at Melbourne University. He completed medical oncology training in Melbourne and worked as the Senior Clinical Research Registrar at Guy’s Hospital, London.

In 1998 arrived in Albury-Wodonga and established a medical oncology practice and clinical trials unit which has developed expertise and infrastructure to ensure the initiation of high quality trials. The research Unit lead by Dr Underhill has twice been awarded NSW Premier’s Award for Innovation in Cancer Clinical Trials, the inaugural award in 2009 and then again in 2012.

Dr Underhill is the VCCC Regional Oncology Lead and advocates for the increased access to clinical trials for regional Victorians and leads the VCCC teletrials program. You can find Craig on Twitter here: @CraigUnderhill 

Rachael Babin

Rachael Babin is Editor-in-Chief of The Oncology Newsletter, Publisher of Oncology News Host of The Oncology Podcast and Producer of The Oncology Journal Club. For regular oncology updates for healthcare professionals, please subscribe to The Oncology Newsletter.

With thanks to Eva Segelov, Craig Underhill, Hans Prenen and Graham Knowles.

Connect with us on Twitter @OncologyNewsAus


About Author

The ONA Editor curates oncology news, views and reviews from Australia and around the world for our readers. In aggregated content, original sources will be acknowledged in the article footer.

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