The OJC Episode 45: Challenges of Cancer Care for the LGBTQ+ Community

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The Oncology Podcast, brought to you by Oncology News Australia, is proud to present Episode 45 in our series The Oncology Journal Club.

In today’s episode Eva Segelov and Craig Underhill cover a great selection of papers. Craig’s main paper discussion is on the St. Gallen International Consensus Guidelines for treatment of early breast cancer. This is a must listen for anyone treating breast cancer and for trainees also.

Eva’s main paper today is on the challenges of cancer care for the LGBTQ+ community – she’s joined by Dr Liz Ahern to discuss this important issue.

About The Oncology Journal Club:

We have taken an old concept and updated it with a new format. In each episode a team of expert contributors will review topical journal papers and interview special guests who are leaders in their fields to help keep you informed of the latest developments on the go.

With The Oncology Podcast – and The Oncology Journal Club in particular – we are aiming to deliver oncology news differently,” Rachael Babin, Editor-in-Chief, Oncology News.

The Oncology Journal Club is hosted by Professor Eva Segelov, from Monash University. Eva is joined by Dr Craig Underhill from Albury-Wodonga and Professor Hans Prenen from Antwerp, Belgium. We hope you enjoy listening and find this a valuable and entertaining resource.

This Week’s Papers:

  1. Khan Burki, T. The challenges of cancer care for the LGBTQ+ community. The Lancet Oncology. Published: July 01, 2021. Access online here.
  2. Improving cancer care for sexual and gender minorities. Joint Statement. Joint Collegiate Council for Oncology. Access online here.
  3. Burstein HJ, et al; Panelists of the St Gallen Consensus Conference. Customizing local and systemic therapies for women with early breast cancer: The St. Gallen International Consensus Guidelines for treatment of early breast cancer 2021. Ann Oncol. 2021 Jul 6:S0923-7534(21)02104-9. doi: 10.1016/j.annonc.2021.06.023. Epub ahead of print. PMID: 34242744. Access online here.

This Week’s Quick Bites:

  1. Hibino, Y. et al. Clinical benefits of precision medicine in treating solid cancers: European Society of Medical Oncology-Magnitude of Clinical Benefit Scale score-based analysis. ESMO Open. 2021 Jun 9;6(4):100187. Access online here.
  2. Lyman GH, et al. Randomized Controlled Trials Versus Real-World Data in the COVID-19 Era: A False Narrative. Cancer Invest. 2020 Nov. Access online here..
  3. Falandry C, et al. Efficacy and Safety of First-line Single-Agent Carboplatin vs Carboplatin Plus Paclitaxel for Vulnerable Older Adult Women With Ovarian Cancer: A GINECO/GCIG Randomized Clinical Trial. JAMA Oncol. 2021 Jun 1. Access online here.
  4. Oster, P., et al. Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies. Gut. 2021 Jul 12. Access online here.
  5. Dahan, L., et al. Randomized Phase II Trial Evaluating Two Sequential Treatments in First Line of Metastatic Pancreatic Cancer: Results of the PANOPTIMOX-PRODIGE 35 Trial. Journal of Clinical Oncology. Access online here.
  6. Kok, PS., et al. Tumor Response End Points as Surrogates for Overall Survival in Immune Checkpoint Inhibitor Trials: A Systematic Review and Meta-Analysis. JCO Precision Oncology 2021 :5, 1151-1159. Access online here.
  7. Larson, K.L., et al. Clinical Outcomes of Molecular Tumor Boards: A Systematic Review. JCO Precision Oncology 2021 :5, 1122-1132. Access online here.

Amazing Article of the Week:

Zhang L, Losin EAR, Ashar YK, Koban L, Wager TD. Gender Biases in Estimation of Others’ Pain. J Pain. 2021 Mar 5:S1526-5900(21)00035-3. doi: 10.1016/j.jpain.2021.03.001. Epub ahead of print. PMID: 33684539.  Access online here.

This Week’s Team:

Professor Eva Segelov

Eva Segelov

Professor Eva Segelov is a Medical Oncologist and is Director of Oncology at Monash University and Monash Health, Melbourne, Victoria, previously Senior Medical Oncologist at St Vincent’s Hospital, St Vincent’s Private Hospital and St Vincent’s Clinic and Associate Professor of Medicine, University of New South Wales.

Eva has an interest in academic clinical trials in GI and breast cancer and has been a member of the AGITG since 2003. She has clinical trials expertise, links with national and international trials groups, and extensive experience with adult medical education.

You can find Eva on Twitter here: @profevasegelov

Dr Craig Underhill

Craig Underhill

Dr Craig Underhill completed his Bachelor of Medicine and Surgery in 1987 at Melbourne University. He completed medical oncology training in Melbourne and worked as the Senior Clinical Research Registrar at Guy’s Hospital, London.

In 1998 arrived in Albury-Wodonga and established a medical oncology practice and clinical trials unit which has developed expertise and infrastructure to ensure the initiation of high quality trials. The research Unit lead by Dr Underhill has twice been awarded NSW Premier’s Award for Innovation in Cancer Clinical Trials, the inaugural award in 2009 and then again in 2012.

Dr Underhill chaired a working party that was instrumental in securing $65 million in federal funding for The Albury Wodonga Regional Cancer Centre which opened in September 2016.

Dr Underhill is the VCCC Regional Oncology Lead and advocates for the increased access to clinical trials for regional Victorians and leads the VCCC teletrials program.

You can find Craig on Twitter here: @CraigUnderhill

Dr Elizabeth Ahearn

Liz Ahern

Dr Ahern is a clinician-researcher dedicated to improving cancer treatments for patients through translational immune-oncology research. She trained as a consultant physician with specialisation in medical oncology and is a Fellow of the Royal Australasian College of Physicians. She undertook PhD candidature in preclinical cancer immunology at the Queensland Institute of Medical Research and submitted her dissertation entitled Targeting receptor activator of NF-kB pathways in combination immunotherapy in July 2020. She is an investigator on four ongoing translational oncology projects arising from her PhD which have received grants to the value of over AUD$3.3M, including a phase IB/II neoadjuvant immunotherapy trial in lung cancer currently recruiting at multiple sites (POPCORN, ANZCTR – Registration). Dr Ahern relocated to Monash in September 2020 to further her career as a clinican researcher in cancer immunology, and is the principal investigator for neuro-oncology trials at Monash. She works clinically at Clinical Trials Centre Clayton, Monash Medical Centre and the Moorabbin Hospital in early phase/phase one trials, CNS, lung and cutaneous cancers and melanoma. Dr Ahern received a Postdoctoral Fellowship scholarship for 2021 from the School of Medicine, Monash University to continue research in tumour immunology and lung cancer.

You can find Liz on Twitter here: @DrLizAhern

Rachael Babin

Rachael Babin is Editor-in-Chief of The Oncology Newsletter, Publisher of Oncology News Host of The Oncology Podcast and Producer of The Oncology Journal Club. For regular oncology updates for healthcare professionals, please subscribe to The Oncology Newsletter.

With thanks to Eva Segelov, Craig Underhill, Hans Prenen and Graham Knowles.

Connect with us on Twitter @OncologyNewsAus


About Author

The ONA Editor curates oncology news, views and reviews from Australia and around the world for our readers. In aggregated content, original sources will be acknowledged in the article footer.

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