The OJC Episode 30: ctDNA Special

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Welcome to the 30th episode of The Oncology Journal Club podcast!

What a milestone – thank you to all our listeners, guests, to everyone who emailed us feedback and said Hi on Twitter, and of course, a big thank you to our Hosts Eva Segelov, Craig Underhill and Hans Prenen.

The Oncology Podcast, brought to you by Oncology News Australia, is proud to present Episode 30 in our series The Oncology Journal Club.

This week the team are talking about ctDNA and liquid biopsies. Craig gets us started with a ‘ctDNA for Dummies’ segment to set the scene and update us on the latest literature.  Hans has two interviews – he chats with Christian Rolfo who is the Vice President of the International Society of Liquid Biopsy and discusses the practical uses of this technology within GI with Lizzy Smyth, a Medical Oncologist and researcher.

About The Oncology Journal Club:

We have taken an old concept and updated it with a new format. In each episode a team of expert contributors will review topical journal papers and interview special guests who are leaders in their fields to help keep you informed of the latest developments on the go.

With The Oncology Podcast – and The Oncology Journal Club in particular – we are aiming to deliver oncology news differently,” Rachael Babin, Editor-in-Chief, Oncology News.

The Oncology Journal Club is hosted by Professor Eva Segelov, from Monash University. Eva is joined by Dr Craig Underhill from Albury-Wodonga and Professor Hans Prenen from Antwerp, Belgium. We hope you enjoy listening and find this a valuable and entertaining resource.


ctDNA for Dummies Papers:

  1. Alix-Panabières, C., Pantel. K,. Liquid Biopsy: From Discovery to Clinical Application.
  2. Alix-Panabières, C., Pantel, K. Challenges in circulating tumour cell research. Nat Rev Cancer 14, 623–631 (2014). https://doi.org/10.1038/nrc3820

Other Useful Links:


This Week’s Team:

Professor Eva Segelov

Eva Segelov

Professor Eva Segelov is a Medical Oncologist and is Director of Oncology at Monash University and Monash Health, Melbourne, Victoria, previously Senior Medical Oncologist at St Vincent’s Hospital, St Vincent’s Private Hospital and St Vincent’s Clinic and Associate Professor of Medicine, University of New South Wales.

Eva has an interest in academic clinical trials in GI and breast cancer and has been a member of the AGITG since 2003. She has clinical trials expertise, links with national and international trials groups, and extensive experience with adult medical education.

You can find Eva on Twitter here: @profevasegelov

Dr Craig Underhill

Craig Underhill

Dr Craig Underhill completed his Bachelor of Medicine and Surgery in 1987 at Melbourne University. He completed medical oncology training in Melbourne and worked as the Senior Clinical Research Registrar at Guy’s Hospital, London.

In 1998 arrived in Albury-Wodonga and established a medical oncology practice and clinical trials unit which has developed expertise and infrastructure to ensure the initiation of high quality trials. The research Unit lead by Dr Underhill has twice been awarded NSW Premier’s Award for Innovation in Cancer Clinical Trials, the inaugural award in 2009 and then again in 2012.

Dr Underhill chaired a working party that was instrumental in securing $65 million in federal funding for The Albury Wodonga Regional Cancer Centre which opened in September 2016.

Dr Underhill is the VCCC Regional Oncology Lead and advocates for the increased access to clinical trials for regional Victorians and leads the VCCC teletrials program.

You can find Craig on Twitter here: @CraigUnderhill

Professor Hans Prenen

Hans Prenen

Professor Hans Prenen is a medical oncologist and head of the phase 1 – early clinical trials unit at the Antwerp University Hospital in Belgium. He is a member of several scientific organisations, published many scientific oncology papers in prestigious journals and is regularly invited for lectures at national and international meetings.  His interests are clinical trials and translational research with a focus on digestive oncology.

You can find Hans on Twitter here: @HPrenen

 

Professor Christian Rolfo

Christian Rolfo

Christian Rolfo, MD, PhD, MBA, Dr.hc. is professor in the Division of Hematology-Oncology at University of Maryland School of Medicine and the Director of the Thoracic Medical Oncology and the Early Clinical Trials at the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC). He specialises in thoracic oncology, drug development and translational oncology.

Dr. Rolfo actively works on drug development and resistance in lung cancer and mesothelioma treatment. His focus of research are liquid biopsies (exosomes and ctDNA) and molecular profiling, he is involved in druggable biomarkers research and immunotherapy in thoracic cancer.

Dr. Rolfo is the Deputy Chair of the Educational Committee of the International Association for the Study of Lung Cancer (IASLC) and Vice President of The International Society of Liquid Biopsy (ISLB). His Twitter handle is: @ChristianRolfo

Dr Lizzy Smyth

Elizabeth (Lizzy) Smyth is an consultant in gastrointestinal oncology at Addenbrooke’s Hospital in Cambridge. Dr Smyth commenced her oncology training in Dublin, Ireland. In 2009 she was awarded an Irish Society of Medical Oncology fellowship to train at Memorial Sloan-Kettering Centre, New York. Following this she worked at the Royal Marsden Hospital in London from 2011-2018. Her research focus is on clinical trials and translational research in gastroesophageal cancer and she has worked on trial design and management of national and international trials. She is a member of the European Society of Medical Oncology Faculty GI educational faculty and in 2017 was elected as secretary of the EORTC GI clinical trials group for the period 2018-2021. Dr Smyth is committed to furthering national and international collaboration in GI trials research.

You can find Lizzy on Twitter here: @LizzySmyth1

Rachael Babin

Rachael Babin is Editor-in-Chief of The Oncology Newsletter, Publisher of Oncology News Host of The Oncology Podcast and Producer of The Oncology Journal Club. For regular oncology updates for healthcare professionals, please subscribe to The Oncology Newsletter.

With thanks to Eva Segelov, Craig Underhill, Hans Prenen, Christian Rolfo, Lizzy Smyth and Graham Knowles.

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ONA Editor

The ONA Editor curates oncology news, views and reviews from Australia and around the world for our readers. In aggregated content, original sources will be acknowledged in the article footer.

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