PRODIGE 7, CRC Mortality, Treatment Delays, Surveillance Mammography, Late Mortality, Tweetations and Saddle Sores!
The Oncology Podcast, brought to you by Oncology News Australia, is proud to present Episode 24 in our series The Oncology Journal Club.
Hans Prenen gets us started with the PRODIGE 7 trial and a comparative study on colorectal cancer mortality in young adults which interestingly is rising USA, Canada and Australia, but not in Europe and Asia.
Eva Segelov gives us insight into delays with the development of a model to estimate the association between delay in cancer treatment and local tumor control and the risk of metastases and sets Craig Underhill a homework task on fractals.
We’ve given Craig a break from main papers this week after last week’s epic episode on ASCO GI which I highly recommend you listen to, if you’ve not already.
Our Quick Bites are a must listen too this week… everyone has something fascinating to share. Where else will you hear about colorectal cancer cells entering a diapause-like DTP state – aka hibernation, tweetations and the public disclosure of identifiable patient information by health professionals on twitter, surveillance mammography for older patients, why Albury is called Smallbury, an Australian study on late mortality in people with cancer and saddle sores among female competitive cyclists.
With the usual top quality banter, papers you won’t hear of anywhere else and expert analysis from our Hosts, you are in for another great episode of The Oncology Journal Club!
About The Oncology Journal Club:
We have taken an old concept and updated it with a new format. In each episode a team of expert contributors will review topical journal papers and interview special guests who are leaders in their fields to help keep you informed of the latest developments on the go.
With The Oncology Podcast – and The Oncology Journal Club in particular – we are aiming to deliver oncology news differently,” Rachael Babin, Editor-in-Chief, Oncology News.
The Oncology Journal Club is hosted by Professor Eva Segelov, from Monash University. Eva is joined by Dr Craig Underhill from Albury-Wodonga and Professor Hans Prenen from Antwerp, Belgium. We hope you enjoy listening and find this a valuable and entertaining resource.
This Week’s Abstracts:
- The OJC Club Episode 21: COVID-19 and Vaccine Update
- The OJC Episode 22: Disparity Special
- The OJC Episode 23: ASCO GI Special
- Quénet F,et al. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2021 Jan 18:S1470-2045(20)30599-4. doi: 10.1016/S1470-2045(20)30599-4. Epub ahead of print. PMID: 33476595. Access online here.
- Santucci, C. et al. Colorectal cancer mortality in young adults is rising in the USA, Canada and Australia, but not in Europe and Asia. Gastroenterology. January 05, 2021. DOI:10.1053/j.gastro.2020.12.070 Access online here.
- Siegel, R. L., et al. Cancer Statistics, 2021. CA: A Cancer Journal for Clinicians. Volume 71, Issue 1, January/February 2021. https://doi.org/10.3322/caac.21654. Access online here.
- Ng J, et al. Development of a Model to Estimate the Association Between Delay in Cancer Treatment and Local Tumor Control and Risk of Metastases. JAMA Netw Open. 2021;4(1):e2034065. doi:10.1001/jamanetworkopen.2020.34065. Access online here.
This Week’s Quick Bites:
- Rehman SK, et al. Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy. Cell. 2021 Jan 7;184(1):226-242.e21. doi: 10.1016/j.cell.2020.11.018. PMID: 33417860. Access online here.
- Hong et al. Distribution of KRASG12C Somatic Mutations across Race, Sex, and Cancer Type. N Engl J Med 2021; 384:185-187. DOI: 10.1056/NEJMc2030638. Access online here.
- Koczwara, B., et al. Late mortality in people with cancer: a population‐based Australian study. Med J Aust || doi: 10.5694/mja2.50879. Access online here.
- The OJC Episode 17: Cardio Oncology Special
- Woolf, S. H., et al. COVID-19 as the Leading Cause of Death in the United States. JAMA. 2021;325(2):123-124. doi:10.1001/jama.2020.24865. Access online here.
- The OJC Episode 21: COVID-19 and Vaccine Update
- Bury, K. et al. A Saddle sores among female competitive cyclists: A systematic scoping review, Journal of Science and Medicine in Sport, https://doi.org/10.1016/j.jsams.2020.10.006. Access online here.
- Ahmed W, et al. Public Disclosure on Social Media of Identifiable Patient Information by Health Professionals: Content Analysis of Twitter Data. J Med Internet Res 2020;22(9):e19746. DOI: 10.2196/19746. Access online here.
- Freedman R.A., et al. Individualizing Surveillance Mammography for Older Patients After Treatment for Early-Stage Breast Cancer: Multidisciplinary Expert Panel and International Society of Geriatric Oncology Consensus Statement. JAMA Oncol. Published online January 28, 2021. doi:10.1001/jamaoncol.2020.7582. Access online here.
- Breast Cancer Association Consortium, et al. Breast Cancer Risk Genes – Association Analysis in More than 113,000 Women. N Engl J Med. 2021 Jan 20. doi: 10.1056/NEJMoa1913948. Epub ahead of print. PMID: 33471991. Access online here.
This Week’s Team:
Professor Eva Segelov
Professor Eva Segelov is a Medical Oncologist and is Director of Oncology at Monash University and Monash Health, Melbourne, Victoria, previously Senior Medical Oncologist at St Vincent’s Hospital, St Vincent’s Private Hospital and St Vincent’s Clinic and Associate Professor of Medicine, University of New South Wales.
Eva has an interest in academic clinical trials in GI and breast cancer and has been a member of the AGITG since 2003. She has clinical trials expertise, links with national and international trials groups, and extensive experience with adult medical education.
Dr Craig Underhill
Dr Craig Underhill completed his Bachelor of Medicine and Surgery in 1987 at Melbourne University. He completed medical oncology training in Melbourne and worked as the Senior Clinical Research Registrar at Guy’s Hospital, London.
In 1998 arrived in Albury-Wodonga and established a medical oncology practice and clinical trials unit which has developed expertise and infrastructure to ensure the initiation of high quality trials. The research Unit lead by Dr Underhill has twice been awarded NSW Premier’s Award for Innovation in Cancer Clinical Trials, the inaugural award in 2009 and then again in 2012.
Dr Underhill chaired a working party that was instrumental in securing $65 million in federal funding for The Albury Wodonga Regional Cancer Centre which opened in September 2016.
Dr Underhill is the VCCC Regional Oncology Lead and advocates for the increased access to clinical trials for regional Victorians and leads the VCCC teletrials program.
Professor Hans Prenen
Professor Hans Prenen is a medical oncologist and head of the phase 1 – early clinical trials unit at the Antwerp University Hospital in Belgium. He is a member of several scientific organisations, published many scientific oncology papers in prestigious journals and is regularly invited for lectures at national and international meetings. His interests are clinical trials and translational research with a focus on digestive oncology.
Rachael Babin is Editor-in-Chief of The Oncology Newsletter and Publisher of www.oncologynews.com.au. For regular oncology updates for healthcare professionals, please subscribe to The Oncology Newsletter.
With thanks to Eva Segelov, Craig Underhill, Hans Prenen and Graham Knowles.