Targeted hormone-radiation treatment slows growth of midgut neuroendocrine tumours

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clock watch time concept_oncology news australiaEarly results from a phase III study of patients with previously treated, advanced midgut neuroendocrine tumours show that a novel therapy, 177Lutetium-DOTATATE (Lutathera), may substantially slow tumour growth.

Patients treated with the experimental drug had a 79% lower risk of disease progression or death compared to those treated with octreotide LAR 60 mg every four weeks.

The study was presented at the 2016 Gastrointestinal Cancers Symposium in San Francisco.

“Our results indicate that Lutathera appears to be a safe and effective treatment option. On average, tumours responded to the drug for several years before they began growing again,” said lead study author Jonathan R. Strosberg, MD, a medical oncologist at the Moffitt Cancer Center in Tampa, FL.

“The new therapy is also more convenient – it requires only four treatments, as opposed to medications that patients have to take daily over long periods of time.”

177Lutetium-DOTATATE belongs to a new class of drugs known as Peptide Receptor Radionuclide Therapy (PRRT), which combine hormone therapy and radiotherapy.

In the case of 177Lutetium-DOTATATE, a somatostatin analogue is attached to a radioactive molecule, enabling targeted delivery of cancer-killing radiation to tumours.

Most patients with metastatic midgut neuroendocrine tumours (i.e., those that begin in the small intestine and proximal colon) receive hormone therapy with a somatostatin analogue, such as octreotide or lanreotide.

There are currently no effective systemic second-line treatment options for patients with tumours that stop responding to somatostatin analogues.

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According to the authors, this is the first prospective, randomised trial to evaluate the efficacy of 177Lutetium-DOTATATE in patients with advanced midgut neuroendocrine tumours.

All 230 trial participants had advanced tumours that worsened despite first-line somatostatin analogue therapy.

The patients were randomly assigned to treatment with 177Lutetium-DOTATATE or high-dose octreotide LAR.

At the time of data analysis, 23 patients in the 177Lutetium-DOTATATE group experienced disease progression, compared to 67 in the octreotide LAR group.

The median progression-free survival was eight months in the octreotide LAR group and was not reached in the 177Lutetium-DOTATATE group.

The preliminary findings of the study also suggest that 177Lutetium-DOTATATE may extend patient survival.

There were substantially fewer deaths in the 177Lutetium-DOTATATE group vs. the standard care group (13 vs. 22). However, longer follow-up is needed to determine the definitive impact of 177Lutetium-DOTATATE on long-term survival.

cancer drugs_plate_oncology news australiaOverall, the numbers of adverse events, including serious side effects, were similar between the two treatment groups. Octreotide often causes gas and bloating and can lead to development of gallstones with long-term use. 177Lutetium-DOTATATE can cause low blood cell counts, which are usually transient.

Neuroendocrine tumours are a group of cancers that begin in hormone-producing (neuroendocrine) cells of various organs in the body. Each year about 8,000 people in the United States are diagnosed with a neuroendocrine tumour of the gastrointestinal tract. While they are rare overall, the incidence of neuroendocrine tumours is on the rise.
[hr] SourceASCO

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