Research on a bacterial toxin first discovered in Adelaide has led to the development a new blood test for the early diagnosis of ovarian cancer—a disease which kills over 1000 Australian women and 150,000 globally each year.
The new blood test has the potential to dramatically improve early detection of the disease, although it will require further testing before it is available for clinicians.
A research team from the University of Adelaide and Griffith University have been studying the interactions between the toxin and an abnormal glycan (sugar) expressed on the surface of human cancer cells and released into the blood.
The team has now engineered a harmless portion of the toxin to enhance its specificity for the cancer glycan and used this to detect it in blood samples from women with ovarian cancer.
A paper published this month in Biochemical and Biophysical Research Communications has shown that the new test detected significant levels of the cancer glycan in blood samples from over 90 percent of women with stage 1 ovarian cancer and in 100 percent of samples from later stages of the disease, but not in any of the samples from healthy controls.
“Ovarian cancer is notoriously difficult to detect in its early stages, when there are more options for treatment and survival rates are better. Our new test is therefore a potential game changer,” says Professor James Paton, Director of the University of Adelaide’s Research Centre for Infectious Diseases.
Professor Michael Jennings, Deputy Director of the Institute for Glycomics at Griffith University, said: “Detection of this tumour marker may also play a role in a simple liquid biopsy to monitor disease stage and treatment.”
The team is currently seeking scientific and commercial partners to further test the technology with larger numbers of patient samples and to adapt it for mass screening.
Paper: L.K. Shewell et al. Detection of N-glycolylneuraminic acid biomarkers in sera from patients with ovarian cancer using an engineered N-glycolylneuraminic acid-specific lectin SubB2M, Biochemical and Biophysical Research Communications (2018). DOI: 10.1016/j.bbrc.2018.11.001