Losing weight lowers levels of proteins associated with tumour growth

Pinterest LinkedIn Tumblr +

rOverweight or obese women who lost weight through diet or a combination of diet and exercise also significantly lowered levels of proteins in the blood that help certain tumours grow, according to a Fred Hutchinson Cancer Research Center study published in Cancer Research, a journal of the American Association for Cancer Research.

The research contributes to a growing body of evidence linking diet and obesity to the risk of developing cancer.

Two study leaders – Dr. Catherine Duggan, principal staff scientist in the Public Health Sciences Division, and Dr. Anne McTiernan, cancer prevention researcher in the Public Health Sciences Division and the article’s senior author – are available to provide details on the study and its implications.

vegan diet concept_oncology news australiaThe study measured three proteins that are known to enhance tumour-related angiogenesis, and was intended to see how cancer-promoting proteins changed when overweight, sedentary, postmenopausal women lost weight through diet or diet and exercise over the course of a year.

The trial enrolled 439 healthy women (no cancer), placing each participant in one of four study arms: Calorie and fat-restricted diet , aerobic exercise five days a week, combined diet and exercise, and a control arm with no intervention.

obese woman oncology news australia_800x500They found that women in the diet arm and the diet and exercise arm lost more weight and had significantly lower levels of angiogenesis-related proteins, compared with women in the exercise-only arm and the control arm.

The authors said that it is known that being overweight and having a sedentary lifestyle are associated with increased risk for developing certain cancers, but the reasons for this relationship are not clear.

This study shows that weight loss may be a safe and effective way to improve the “angiogenic profile” of healthy individuals, meaning they would have lower blood levels of cancer-promoting proteins.

Although the researchers cannot say for certain that this would impact the growth of tumours, they believe there could be an association between reduced protein levels and a less favourable environment for tumour growth.
[hr] SourceCancer Research


About Author

ONA Editor

The ONA Editor curates oncology news, views and reviews from Australia and around the world for our readers. In aggregated content, original sources will be acknowledged in the article footer.

Comments are closed.