Chimeric Antigen Receptor T-cell therapy, also known as CAR T therapy, was named the biggest research breakthrough of 2017 by the American Society of Clinical Oncology.
The personal gene therapy utilises a patient’s own immune cells to fight cancer.
The Food and Drug Administration has approved CAR T therapy products for adults with diffuse large B-cell lymphoma and paediatric and young adults suffering from acute lymphoblastic leukaemia.
Now, researchers at Moffitt Cancer Center are working to expand this revolutionary therapy to other cancers.
One possible disease that could benefit is acute myeloid leukaemia (AML), the most common acute leukaemia affecting adults.
More than half of AML patients go into remission after chemotherapy.
However, many relapse because residual leukaemia cells can evade chemotherapy and the immune system.
A new phase 1 trial called the THINK (THerapeutic Immunotherapy with NKG2D) study is investigating Celyad’s new CAR T therapy CYAD-01 which genetically modifies immune cell to express a natural killer receptor that targets leukaemia tumours.
According to a case study from trial published online ahead of print in the journal Haematologica, a patient has remained cancer free for nine months after being treated with CYAD-01, followed by a bone marrow transplant.
“It is important to note this is the first time CAR T has induced a remission in AML,” said case study author David Sallman, M.D., assistant member of the Department of Malignant Hematology at Moffitt.
“It is also the first time CAR T has been effective without the need of preconditioning chemotherapy.”
For CAR T treatment, T cells are removed from a patient’s blood and sent to a lab where the cells are genetically modified to better enable them to identify and attack cancer cells.
Once the new cells are received, patients typically receive preconditioning chemotherapy to deplete their immune system to make room for the new cells.
In the THINK study, no preconditioning chemotherapy was necessary.
“Our case study shows that CAR T therapy is a viable option for AML patients,” added Sallman. “We now need to take what we have learned in this initial study and expand the trial.”