Mapping residual oesophageal tumours – a glimpse into the future?

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It’s one of the first questions asked by many newly-diagnosed cancer patients – “What are my chances of beating this?”

Often there is no clear answer, with survival rates differing widely depending on the cancer stage and available treatment options.

However, post-operative testing that provides an accurate prediction of long-term treatment outcomes is the next best thing to a crystal ball, allowing clinicians to plan further treatment or follow-up strategies and more accurately inform patients about their prognoses.

But is this possible?

Researchers in Japan think that it might be, at least for oesophageal cancer patients.

In a recent study published in Annals of Surgery, a team led by researchers at Osaka University retrospectively examined tissue specimens from 120 oesophageal cancer patients following treatment, allowing them to both assess tumour characteristics and investigate how these related to long-term treatment outcomes.

Oesophageal cancer is the sixth most common cause of cancer-related death worldwide and, despite various treatment options, has a poor long-term prognosis.

Most locally-advanced esophageal cancers are treated with neoadjuvant chemotherapy (NAC), which aims to increase the likelihood of successful curative surgery by reducing tumour size and eradicating systemic micro-metastases.

Tissue specimens are usually examined after surgery to assess how a tumour has responded to chemotherapy treatment.

However, standard methods do not map the remaining tumour cells to the different layers of the oesophageal wall, and therefore provide an incomplete picture of treatment outcome.

The team hypothesised that there might be specific patterns of residual tumours after NAC, and that they might have different clinical implications for patients.

The researchers therefore mapped the exact locations of residual tumours in the oesophageal wall of patients after NAC and assessed whether tumour location was associated with clinicopathological parameters including specific oncological outcomes.

After NAC, they identified four tumour remnant patterns that are clearly different from those reported previously; the most common residual tumour pattern was a ‘shallow type.’

However, in approximately 40% of cases, tumour cells unexpectedly disappeared in the superficial (mucosal) layer of the esophageal wall, indicating that it would be difficult to diagnose whether or not tumour cells completely disappeared after NAC based only on an endoscopic mucosal biopsy.

When the team examined associations between these patterns and disease factors, including prognosis, they found that pattern types 3 and 4 had higher risks of pleural dissemination and distant metastases than types 1 or 2.

These results shows that patients displaying patterns 3 or 4 should have more regular follow-up appointments than those with pattern types 1 or 2.

Interestingly, survival was similar among the four groups.

According to lead authors Tadayoshi Hashimoto and Tomoki Makino, these findings have significant clinical implications.

They explained that by determining the tumour remnant pattern from resected specimens and post-operative image examination, a personalised treatment plan for each patient can be developed.

This customised approach is expected to significantly improve esophageal cancer treatment outcomes.


Source: Osaka University

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The ONA Editor curates oncology news, views and reviews from Australia and around the world for our readers. In aggregated content, original sources will be acknowledged in the article footer.

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