First US trial of procedure to relieve pain from spinal tumours

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spine_oncology news australiaWhen metastatic cancer spreads to the spine, it can cause spinal fractures, severe pain and impaired mobility.

Loyola University Medical Center has launched the first clinical trial in the United States of a minimally invasive treatment designed to help relieve pain, heal spinal fracturesand prevent new fractures.

In metastatic cancer, the most common sites the cancer spreads to are bones, and the spine is the most common site of bone metastases. A tumour can weaken a vertebra, causing it to collapse on itself.

Loyola will test a new combination treatment that delivers radiation directly to the tumour and increases support of the spine.

First, an interventional radiologist makes a small incision into the spine and inserts a spinal applicator needle to deliver radiation directly to the tumour (intraoperative radiotherapy). Because it is more precise than standard external beam radiation, intraoperative radiotherapy can deliver a higher dose of radiation, while minimising adverse effects to normal tissue.

The second half of the operation is a procedure called a kyphoplasty. A catheter is inserted through the incision. A balloon at the tip of the catheter is inflated to increase the height of the collapsed vertebra. A cement-like material then is injected into the radiated area to help stabilise the spine.

The purpose of the Phase 1 study is to learn about both the good and bad effects of combining intraoperative radiotherapy and kyphoplasty. Researchers will compare the pain levels and use of pain medications before and after the procedure. They also will monitor quality-of-life issues, the effect of the procedure on the tumour and any complications.

The study is titled “Combining Intraoperative Radiotherapy with Kyphoplasty for Treatment of Spinal Metastases (Kypho-IORT )”. It is sponsored by the departments of Radiation Oncology and Radiology of Loyola University Chicago Stritch School of Medicine.

Source: Loyola University

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