Drug that targets key mutation found to shrink some tumours

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A team of researchers affiliated with several institutions in the U.S. and Australia has found that a drug they optimised to target a protein produced due to mutations in the genome was able to shrink some tumours in mice and humans. In their paper published in the journal Nature, the group describes the drug and how well it worked on test subjects.

As the researchers point out, the Kirsten rat sarcoma (KRAS) viral oncogene homolog is the most frequently seen mutation in human tumour formation—for unknown reasons, it becomes stuck in the “on” position, which makes cells create proteins that can lead to the formation of cancerous tumours. Medical scientists have known about the problems it can create for several decades, but have been powerless to stop it. In this new effort, the researchers have optimised a drug that shows promising results in doing just that.

The researchers were able to optimise a drug to target the protein when they discovered grooves on the KRAS protein—that allowed them to create a drug that binds to it and prevents it from taking part in tumour formation. The drug they developed is called AMG 510. The researchers tested it first on mice and found it very effective in reducing tumour growth, and in some cases, eradicating them altogether.

Emboldened by their results, the researchers gave the drug to four lung cancer patients. They report that after six weeks, two of the patients saw reductions in tumour size—one by 34 percent, the other 67 percent. The other two patients saw no change in tumour size.

The researchers report that they also found that giving AMG 510 to mice not only shrunk their tumours, it also had an impact on their immune system. They found that in some cases, even after they stopped giving the drug to the mice, their bodies would no longer grow tumours—their immune systems had been bolstered, allowing the mice to fight off tumour growth on their own. In other cases, giving the mice AMG 510 appeared to make other drugs more effective against tumour growth.


Paper: Jude Canon et al. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity, Nature (2019). DOI: 10.1038/s41586-019-1694-1

Source: Nature
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The ONA Editor curates oncology news, views and reviews from Australia and around the world for our readers. In aggregated content, original sources will be acknowledged in the article footer.

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