Cancer therapies including radiation and chemotherapy seek to treat the disease by killing tumour cells.
Now a team including researchers at Beth Israel Deaconess Medical Center (BIDMC) have shown that the dead and dying cancer cells generated by chemotherapy and targeted cancer therapy paradoxically trigger inflammation that promotes aggressive tumour growth.
In a study published today in the Journal of Experimental Medicine, the team has illuminated the mechanism by which tumour cell death can drive primary tumour growth and metastasis.
Moreover, the scientists also demonstrated that this unintended consequence of cancer treatment can be halted by resolvins, a family of molecules naturally produced by the human body.
The findings represent a novel treatment approach to preventing tumour growth and recurrence.
“In this study we demonstrate that chemotherapy-generated debris from dead and dying tumour cells can stimulate tumour growth, which has pivotal implications for the treatment of cancer patients,” said senior author Dipak Panigrahy, MD, assistant professor of pathology in the Department of Pathology.
“Conventional cancer therapy designed to kill tumour cells is inherently a double-edged sword.”
The findings are consistent with clinical observations on radiation-generated debris dating back to the 1950s, but until now, few studies investigated the molecular mechanisms underlying the phenomenon.
In these studies, Panigrahy, a scientist at the Cancer Center at BIDMC, and colleagues – including lead author Megan Sulciner of BIDMC, Charles N. Serhan, Ph.D., of Brigham and Women’s Hospital (BWH), Mark W. Kieran, MD, PhD of Dana-Farber Cancer Institute, and Sui Huang, MD, PhD, of Institute of Systems Biology – injected debris from tumour cells killed by chemotherapy into animal models.
Thirteen months later, the tumour cell debris alone had produced no visible tumours.
However, when the researchers co-injected tumour cell debris together with as few as 100 living cancer cells that would not have resulted in cancer by themselves, the combination promoted rapid tumour growth.
The researchers’ further analysis revealed that chemotherapy-killed cancer cells promote growth when a lipid molecule exposed on the surface of dead and dying cells triggers the release of cytokines – proteins that regulate the body’s immune and inflammatory response.
The resulting “cytokine storm” in the tumour’s microenvironment in turn sets the stage to promote new tumour growth.
“This pro-tumour activity could fuel a positive feedback loop that is difficult to overcome with more aggressive cytotoxic therapy like chemotherapy and radiation,” said Panigrahy.
“This may explain the inherent therapeutic limit to cancer treatments available today.”
In another set of experiments, Panigrahy and colleagues attempted to block debris-stimulated tumour growth by introducing a class of anti-inflammatories produced by the human body called resolvins.
Discovered by Serhan and colleagues at BWH in 2002, resolvins actively turn off inflammation and stimulate a class of immune cells to digest the tumour debris left in the wake of the cytokine storm.
In this study, resolvins suppressed lung and melanoma metastasis in mouse models, the scientists found, and blocked cancer growth in various tumour models including lung, pancreatic, lymphoma, breast, prostate, and melanoma.
When the researchers administered chemotherapy and resolvins to a debris-stimulated pancreatic cancer model in mice, the combination resulted in tumour regression.
The findings open the door to a new approach to prevent cancer recurrence as well as treatment by adding resolvins to existing chemotherapy of targeted therapy regimens.
Already in clinical development as a potential treatment for other inflammatory disease including eczema, periodontal disease and various neurodegenerative disease, resolvins have proven to be non-toxic and come with minimal side-effects.